Whole-grain intake favorably affects markers of systemic inflammation in obese children: A randomized controlled crossover clinical trial.

The following is from Info source:

http://www.ncbi.nlm.nih.gov/m/pubmed/24478050/ for your convenience. 

=========

AuthorsHajihashemi P, et al. Show all Journal

Mol Nutr Food Res. 2014 Jan 30. doi: 10.1002/mnfr.201300582. [Epub ahead of print]

Affiliation

Abstract

---------

SCOPE: 

======

Whole-grain foods have been reported to affect serum levels of inflammatory cytokines. However, we are aware of no study examining the effect of whole-grain intake on inflammatory biomarkers among children. The present study aimed to determine the effect of whole-grain intake on serum levels of inflammatory biomarkers in overweight or obese children.

METHODS AND RESULTS: 

=========

In this randomized crossover clinical trial, 44 overweight or obese girls aged 8-15 years participated. After a 2-week run-in period, subjects were randomly assigned to either whole-grain or control groups. Subjects in the whole-grain group were given a list of whole-grain foods and were asked to obtain half of their needed servings of grains from whole-grain foods each day for 6 weeks. 

Individuals in the control group were also given a list of whole-grain foods and were asked not to consume any of these foods during the intervention phase of the study. A 4-week washout period was applied following which subjects were crossed over to the alternate arm for an additional 6 weeks. Fasting blood samples were taken before and after each phase of the study to quantify markers of systemic inflammation. Mean age, weight, and BMI of study participants were 11.2 ± 1.49 years, 51.2 ± 10.2 kg, and 23.5 ± 2.5 kg/m(2) , respectively. No significant effect of whole-grain intake on weight and BMI was seen compared with the control group. 

We found a significant effect of whole-grain intake on serum levels of high-sensitive C-reactive protein (-21.8 versus +12.1%, p = 0.03), soluble intercellular adhesion molecule-1 (-28.4 versus +6.3%, p = 0.02), serum amyloid A (-17.4 versus +9.9%, p = 0.02), and leptin (-9.7 versus +39.2%, p = 0.02) after 6 weeks. A trend toward the significant effect of whole-grain intake on serum levels of soluble vascular cell adhesion molecule-1 (-36.2% versus -7.8%, p = 0.07) was also observed.

CONCLUSION: 

=========

This study provides evidence supporting the beneficial effects of whole-grain foods on biomarkers of systemic inflammation in obese children.

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID 24478050 [PubMed - as supplied by publisher]

Full text: John Wiley & Sons, Inc.

Related Citations

=======

•• Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods.

•• Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects.

•• Effects of wheat and oat-based whole grain foods on serum lipoprotein size and distribution in overweight middle aged people: a randomised controlled trial.

•• Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults.

Effects of synbiotic food consumption on metabolic status of diabetic patients: a double-blind randomized cross-over controlled clinical trial.