【北大校长读错字以后，全民都注意字的读音了】——经常念错的100 字 正确读音。单音字括号内为正确读音，看看你读错了多少：
恬(甜)静 包庇(毕) 酗(序)酒 造诣(义) 揠(亚)苗 粗犷(广) 木屑(谢) 绚(炫)丽 谄(产)媚 棘(集)手 机械(泻) 砧(真)板 谒(页)见 舐(是)犊 拯(整)救 箴(珍)言 翌(艺)日 哺(补)育 恪(客)守 赏赐(次) 书笺(肩) 贮(注)存 修葺(泣) 纨绔(裤) 阐(产)述 迁徙(喜) 瑰(归)宝 澎湃(派) 同胞(包) 簇(醋)拥 麻痹(毕) 濒(宾)临 玷(电)污 罹(梨)难 嗾(叟)使 鞭笞(吃) 饿殍(瞟) 逮捕(补) 粗糙(操) 拂(服)晓 嗔(抻)怒 炽(赤)热 歼(肩)灭 发酵(叫) 狙(拘)击 憧(充)憬 糟粕(破) 掮(前)客 干涸(河) 畸(基)形 咆(袍)哮 手帕(怕) 翩跹(仙) 蓦(漠)然 脍(快)炙 褴褛(旅) 抚恤(序) 愤懑(闷) 龋(取)齿 桎梏(固) 按捺(纳) 回溯(诉) 鞭挞(蹋) 塑(诉)料 狡黠(匣) 瞠(撑)目 媲(屁)美 讣(副)告 斡(沃)旋 联袂(妹) 赈(镇)济 汲(鸡)取 浸(进)透 刚愎(闭) 窠(科)臼 潸(山)然 妊娠(身) 阴霾(埋) 惴(坠)惴 栉(至)风 膏肓(荒) 百舸(ge上声) 淙(丛)淙 针砭(匾)
咳嗽(sou去声)莅(粒)临 取缔(第) 证券(劝) 喟(溃)然 嫩(nen去声)叶
混淆(xiao阳平) 谬(miu去声)论 湍(tuan阴平)急 冗(rong上声)长
吸吮(shun上声) 高耸(song上声)怂(song上声)恿 怙(户)恶不悛(quan阴平)
酝酿(niang去声) 铿(坑)锵(枪) 悚(song上声)然 唾(tuo去声)弃
容易读白字的词和成语的正确读音 恫吓(贺) 要挟(邪) 呜咽(业) 拓(榻)片 禅(善)让 呆(癌)板 凹(ao阴平)陷 叨(涛)扰 提(低)防 堆(dui阴平)积 咯(卡)血 龟(君)裂 屏(丙)息 侧(摘)歪 亲(庆)家 参(cen阴平)差(ci阴平)不齐 数(朔)见不鲜 自怨自艾(义) 否(匹)极泰来 审时度(夺)势 心宽体胖(盘) 一曝(铺)十寒 一叶扁(篇)舟 大腹便便(pian pian阳平) 瓜熟蒂(第)落。
Tuesday, May 29, 2018
经常念错的100字正确读音
Monday, May 28, 2018
Curcumin inhibits aggregation of α-synuclein
https://link.springer.com/article/10.1007/s00401-007-0332-4
See also ==> http://hl123.blogspot.sg/2018/05/httpswww.html?m=1
Abstract
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Aggregation of amyloid-beta protein (Aβ) is a key pathogenic event in Alzheimer’s disease (AD). Curcumin, a constituent of the Indian spice Turmeric is structurally similar to Congo Red and has been demonstrated to bind Aβ amyloid and prevent further oligomerization of Aβ monomers onto growing amyloid β-sheets. Reasoning that oligomerization kinetics and mechanism of amyloid formation are similar in Parkinson’s disease (PD) and AD, we investigated the effect of curcumin on α-synuclein (AS) protein aggregation. In vitro model of AS aggregation was developed by treatment of purified AS protein (wild-type) with 1 mM Fe3+ (Fenton reaction). It was observed that the addition of curcumin inhibited aggregation in a dose-dependent manner and increased AS solubility. The aggregation-inhibiting effect of curcumin was next investigated in cell culture utilizing catecholaminergic SH-SY5Y cell line. A model system was developed in which the red fluorescent protein (DsRed2) was fused with A53T mutant of AS and its aggregation examined under different concentrations of curcumin. To estimate aggregation in an unbiased manner, a protocol was developed in which the images were captured automatically through a high-throughput cell-based screening microscope. The obtained images were processed automatically for aggregates within a defined dimension of 1–6 μm. Greater than 32% decrease in mutant α-synuclein aggregation was observed within 48 h subsequent to curcumin addition. Our data suggest that curcumin inhibits AS oligomerization into higher molecular weight aggregates and therefore should be further explored as a potential therapeutic compound for PD and related disorders.
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Abnormal amount of a protein called alpha-synuclein. AND Multiple System Atrophy.
https://www.mayoclinic.org/diseases-conditions/multiple-system-atrophy/symptoms-causes/syc-20356153
MSA causes deterioration and shrinkage (atrophy) of portions of your brain (cerebellum, basal ganglia and brainstem) that regulate internal body functions, digestion and motor control.
Under a microscope, the damaged brain tissue of people with MSA shows nerve cells (neurons) that contain an abnormal amount of a protein called alpha-synuclein. Some research suggests that this protein may be overexpressed in multiple system atrophy.
Thursday, May 17, 2018
Monday, May 14, 2018
Health supplements taken by Hl123 on 20180514. 9.50 pm.
Health supplements taken by HL123 on 2018-05-14. 9.50 pm.
Monday, May 7, 2018
Kin no mame seaweed shop addresses 20180120 obtained from its pop up stall at Orchard Central.
Kin no mame seaweed shop addresses 20180120 obtained from its pop up stall at Orchard Central.
Tuesday, May 1, 2018
Nutrition and the brain.
Nutrition and the brain.
Review article
Morley JE. Clin Geriatr Med. 2010.
Show full citation
Abstract
Severe nutritional deficiencies, such as protein energy malnutrition and deficiency of nicotinamide, vitamin B(12), folate, and thiamine, have long been recognized to cause severe confusion. Lesser vitamin deficiencies have been linked to the pathogenesis of delirium. Hypo- and hyperglycemia and hypertriglyceridemia can cause cognitive deficits. Epidemiologic and animal studies have linked several other nutrients (omega-3 fatty acids, lutein, alpha-lipoic acid, and the Mediterranean diet) to cognitive performance and the prevention of dementia.
PMID
20176295 [Indexed for MEDLINE]
https://www.ncbi.nlm.nih.gov/m/pubmed/20176295/
