https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650738/
Abstract
Genetic, androgenic, epigenetic, environmental, lifestyle, diet, and nutritional factors have influence over promoting or regulating inflammation, immunity, and genetic expression predisposing to hair loss. Oxidative stress is a major mediator for various mechanisms of hair loss, including the release of transforming growth factor-β ( TGF-β). Nutrients counter oxidative stress, repair cellular damage, support cellular functions, and restore hair growth. Nutrients can be synergistic or antagonistic. Covert subclinical nutritional deficiencies are common. Higher dose of nutrients does not mean higher efficiency but may reverse the benefits converting an antioxidant to become prooxidant. Nutrients do not work alone but are supported by accessory micronutrients which ensure biological utilization. Providing proper nutritional environment can neutralize free radicals and perpetuate active hair growth cycles.
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Conclusion
Nutrients can block the release of DHT-induced TGF-β, counter micro-inflammation, oxidative stress, improve immunity, and improve genetic expression which are the basic mechanisms of hair loss. Apart from genetics, lifestyle and nutritional imbalances can predispose to nongenetic and nonandrogenic hair loss. Nutrients have a direct role in restoring hair growth. Nutrients support the action of one another and also influence stem cell function. Further research is required on the specific role and benefit of nutrients in hair loss management especially in patients presenting with normal androgen levels
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