People at Risk of a Vitamin B12 Deficiency
- Older Adults who have Atrophic Gastritis - A condition affecting 30-50% of adults over age 50 and hampers their ability to absorb vitamin B12 from natural foods. Supplements are recommended for people in this group.
- People with Pernicious Anemia - A condition that affects 1-2% of adults and can only effectively be treated with vitamin B12 injections or shots.
- Vegans and Vegetarians - Vitamin B12 is naturally found in animal products, however there are some natural vegetarian foods high in vitamin b12and various fortified B12 foods for vegans.
- Pregnant and Lactating Women who are Vegetarian or Vegan
- People taking Certain Medications
- Proton pump inhibitors, such as omeprazole (Prilosec®) and lansoprazole (Prevacid®), which are used to treat gastric or pepetic ulcer disease can inhibit absorption of vitamin B12.
- Metformin - often used for type II diabetes, may interfere with vitmain B12 absorption in certain people.
- Histamine antagonists, such as cimetidine (Tagamet®), famotidine (Pepcid®), and ranitidine (Zantac®), used to treat peptic ulcer disease, can reduce absorption of vitmain B12 by slowing the release of hydrochloric acid into the stomach.
- Bacteriostatic Antibiotics, like Chloramphenicol (Chloromycetin®), can interfere with the red blood cell response to vitamin b12 supplements.
- Anticonvulsants - Anticonvulsants have been shown to interfere with vitamin B12 and vitamin B9 (Folate) metabolism.19-21 One study found that people taking folate supplements and anticonvulsants experienced a 50% decline in Vitamin B12 blood levels.
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