Calorie Restriction Mimetics (CRM)

https://en.m.wikipedia.org/wiki/Caloric_restriction_mimetic

Calorie restriction mimetics (CRM), also known as Energy restriction mimetics, designate a hypothetical class of dietary supplement or drug candidate that would in principle mimic the substantial anti-aging effects that calorie restriction (CR) has on many laboratory animals. CR is defined as a reduction in calorie intake of 20% (mild CR) to 50% (severe CR) without incurring malnutrition or a reduction in essential nutrients.