白藜芦醇 benefits YouTube in Chinese
https://youtu.be/2ANJeorF764
Sunday, April 30, 2017
The amounts of resveratrol in natural foods
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990065/#!po=7.79817
The amounts of resveratrol in natural foods
Health benefits of Resveratrol
Health benefits of Resveratrol
http://www.life-enhancement.com/magazine/article/3233-resveratrol-ups-memory-performance
Resveratrol as a Calorie Restriction Mimetics (CRM)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133883/
Resveratrol
Resveratrol is a polyphenol compound isolated from the skins of red grapes. Resveratrol is currently the most thoroughly studied CRM. As a CRM, resveratrol was first identified by Sinclair through screening of small molecular libraries for compounds that activate Sirtuin and extend lifespan in a yeast model (56). In that study, they demonstrated that resveratrol can mimic the benefits associated with caloric restriction, and that caloric restriction did not further extend the lifespan of yeast grown in resveratrol supplemented medium. Resveratrol was subsequently shown to extend longevity in worms, flies, fish, and obese mice (57,58). However, a recent study showed that resveratrol had no effect on the longevity of mice fed a normal diet (59). Although the longevity extension effect of resveratrol is not yet certain, it is accepted that resveratrol can improve health and prevent age-related diseases. Further investigations and clarifications are required to verify whether resveratrol is a true CRM.
What is "CALORIC RESTRICTION MIMETICS"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133883/
Although the beneficial effects of caloric restriction on lifespan and health have been clearly demonstrated, it is difficult to implement such restrictions in our lives.
To overcome these difficulties, gerontologists and biologists are attempting to develop drugs to mimic the beneficial effects of caloric restriction without the need for diet limitations.
Such medicines are known as caloric restriction mimetics (CRM).
CALORIC RESTRICTION MIMETICS (CRM)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133883/
CALORIC RESTRICTION MIMETICS
Although the beneficial effects of caloric restriction on lifespan and health have been clearly demonstrated, it is difficult to implement such restrictions in our lives. To overcome these difficulties, gerontologists and biologists are attempting to develop drugs to mimic the beneficial effects of caloric restriction without the need for diet limitations. Such medicines are known as caloric restriction mimetics (CRM).
Resveratrol
Resveratrol is a polyphenol compound isolated from the skins of red grapes. Resveratrol is currently the most thoroughly studied CRM. As a CRM, resveratrol was first identified by Sinclair through screening of small molecular libraries for compounds that activate Sirtuin and extend lifespan in a yeast model (56). In that study, they demonstrated that resveratrol can mimic the benefits associated with caloric restriction, and that caloric restriction did not further extend the lifespan of yeast grown in resveratrol supplemented medium. Resveratrol was subsequently shown to extend longevity in worms, flies, fish, and obese mice (57,58). However, a recent study showed that resveratrol had no effect on the longevity of mice fed a normal diet (59). Although the longevity extension effect of resveratrol is not yet certain, it is accepted that resveratrol can improve health and prevent age-related diseases. Further investigations and clarifications are required to verify whether resveratrol is a true CRM.
Rapamycin
Rapamycin, an antibiotic, immune-suppressor drug, is another proposed CRM that has shown a longevity benefit. After studies showing the extension of replicative lifespan of yeast via inhibition of the TOR signaling in response to rapamycin treatment (60), it was reported that rapamycin extends the median and maximum lifespan of 20-month-old mice accompanied with a decrease in TOR activity (61). Since then, many studies have been conducted to ascertain the function of rapamycin as a CRM. However, it is important to note that there is evidence showing adverse side-effects of rapamycin such as an increase in the incidence of diabetes (62).
Metformine
Metformin is another CRM of interest to gerontologists. Metformin is a biguanide used as a drug for treatment of type-2 diabetes that increases insulin sensitivity and activates AMPK. Metformin received a great deal of attention after it was identified in a screening assay of drugs showing similar transcriptional profiles to that of caloric restriction in mice (63). Moreover, metformin was shown to have a caloric restriction-related longevity benefit mediated by the activation of AMPK in C. elegans (64). Metformin also has a beneficial effect on other aspects of the aging process such as a decrease in age-related disease incidence. However, the longevity benefit of metformin was not observed in a Drosophila model in a recent study (65), or in the non-disease rodent model (66). The appearance of evidence showing that metformin is ineffective on longevity in some species has led to uncertainty as to whether metformin is a true CRM.
CONCLUSIONS
As the number of elderly people who cannot undergo physical activities has increased, anti-aging has become one of the ultimate goals of gerontologists. Although it has been 75 years since the beneficial effects of caloric restriction on animal health were first reported, the underlying mechanism of longevity extension in response to food restriction has still not been identified. Further organized and global investigations encompassing various research fields using well-developed genetic model animals and well-controlled practical human studies will enable the aging process to be controlled, thus allowing humans to live healthier and happier lives in the near future.
Calorie Restriction Mimetics (CRM)
https://en.m.wikipedia.org/wiki/Caloric_restriction_mimetic
Calorie restriction mimetics (CRM), also known as Energy restriction mimetics, designate a hypothetical class of dietary supplement or drug candidate that would in principle mimic the substantial anti-aging effects that calorie restriction (CR) has on many laboratory animals. CR is defined as a reduction in calorie intake of 20% (mild CR) to 50% (severe CR) without incurring malnutrition or a reduction in essential nutrients.
Whey: The New CR (Calorie Restriction) Powerhouse
http://www.lifeextension.com/Magazine/2013/9/New-Longevity-Benefits-of-Whey-Protein/Page-01?utm_source=facebook&utm_medium=social&utm_campaign=normal
The following is adapted from the above web link.
Whey: The New CR Powerhouse
=================
**Although whey is often viewed simply as a protein source, emerging evidence indicates that the branched-chain amino acids (BCAAs) and other fractions found in whey act as a calorie restriction-mimetic.
**Studies on middle-aged animals demonstrate that supplementing with the branched chain amino acids and other components in whey increase median life span by up to the equivalent of 9.6years in human terms!
**This effect is modulated along typical CR pathways—boosting mitochondrial biogenesis, reactive oxygen species (ROS) defense, cell signaling, and expression of sirtuin 1 (SIRT1)—the mammalian longevity gene CR.
**Whey constituents increase median, but not maximum, life span—indicating disease prevention at work. And whey’s protection against age-related diseases has been separately confirmed.
**Whey offers an ideal supplement to secure calorie restriction’s life extension benefits—without the rigors of a low calorie regime.
Protect telomeres and decelerate aging with 4 common vitamins
http://www.naturalhealth365.com/telomeres-aging-2105.html
The following is adapted from the above web link.
==========
The following four common and inexpensive vitamins have all been shown to be beneficial to telomeres.
B-complex vitamins
B-complex vitamins – especially B-6, B-12 and folate – help the body dispose of homocysteine, which interferes with the activity of telomerase. They also support normal cell replication, and are essential for the manufacture of DNA.
Having high levels of homocysteine, along with low levels of B-complex vitamins, is associated with premature shortening of telomeres. It is clear that avoiding vitamin B deficiency is an important part of preserving telomere length.
Another great reason to maintain healthy levels of these three B-complex vitamins is that they are needed for production of SAMe – or S-adenosyl methionine, a compound that helps telomeres work properly.
Good sources of B-complex vitamins include grass-fed meats, wild-caught fish, pasture-raised eggs, organic whole grains, legumes and berries.
Vitamin D
Studies have shown that higher levels of vitamin D are associated with longer telomeres.
In a 2012 study published in International Journal of Obesity, overweight participants who took 2000 IU of vitamin D a day increased their telomere length by close to 20 percent – a significant lengthening.
In another study, women with the highest levels of vitamin D had telomeres five years “younger” than women with the lowest levels.
Researchers think that vitamin D preserves telomere length by promoting the activity of the telomere-repairing enzyme telomerase. You can up your dietary intake of vitamin D with fatty, cold-water fish such as salmon and grass-fed beef liver, organic egg yolks or raw milk.
Vitamin C
In studies of human blood vessel cells, vitamin C had a dramatic effect on telomere shortening, reducing it up to 62 percent over untreated cells. A powerful antioxidant, vitamin C also reduces free radical damage to our cells.
In a recent study of a cellular model of Werner Syndrome, a premature aging disorder, vitamin C was the most effective of numerous compounds in lengthening telomeres, decreasing the production of inflammatory cytokines and improving the cellular nuclei.
You can increase your intake of dietary vitamin C with supplementation and a diet rich in citrus fruits like, oranges and grapefruits; kiwi fruit, red bell peppers, strawberries plus lots of dark leafy greens like kale.
Vitamin E
Vitamin E, which exists in eight different forms of assorted tocopherols and tocotrienols, has been shown to literally “repair” telomeres by correcting malfunctions. Like vitamin C, vitamin E can reduce the chemical stressors that shorten telomeres.
In an intriguing study of aging human cells, researchers found that treating them with a tocotrienol-rich formula reversed age-related changes, making the treated cells resemble “younger “cells – right down to the longer telomeres, reduced DNA damage, and ability to replicate.
The alpha-tocopherol form of vitamin E was found to dramatically slow age-related telomere shortening – with the lengthening effect persisting even as the cells reached middle age.
Good sources of vitamin E include organic almonds, spinach, wheat germ, butternut squash and sunflower seeds.
Friday, April 28, 2017
Understanding omega-3 polyunsaturated fatty acids.
The following is repeated here for your convenience.
Understanding omega-3 polyunsaturated fatty acids.
Calder PC1, Yaqoob P.
Author information
Abstract
Current intakes of very long-chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are low in most individuals living in Western countries. A good natural source of these fatty acids is seafood, especially oily fish. Fish oil capsules contain these fatty acids also. Very long-chain omega-3 fatty acids are readily incorporated from capsules into transport (blood lipids), functional (cell and tissue), and storage (adipose) pools. This incorporation is dose-dependent and follows a kinetic pattern that is characteristic for each pool. At sufficient levels of incorporation, EPA and DHA influence the physical nature of cell membranes and membrane protein-mediated responses, lipid-mediator generation, cell signaling, and gene expression in many different cell types. Through these mechanisms, EPA and DHA influence cell and tissue physiology and the way cells and tissues respond to external signals. In most cases the effects seen are compatible with improvements in disease biomarker profiles or health-related outcomes. As a result, very long-chain omega-3 fatty acids play a role in achieving optimal health and in protection against disease. Long-chain omega-3 fatty acids not only protect against cardiovascular morbidity but also against mortality. In some conditions, for example rheumatoid arthritis, they may be beneficial as therapeutic agents. On the basis of the recognized health improvements brought about by long-chain omega-3 fatty acids, recommendations have been made to increase their intake. The plant omega-3 fatty acid, alpha-linolenic acid (ALA), can be converted to EPA, but conversion to DHA appears to be poor in humans. Effects of ALA on human health-related outcomes appear to be due to conversion to EPA, and since this is limited, moderately increased consumption of ALA may be of little benefit in improving health outcomes compared with increased intake of preformed EPA + DHA.
https://www.ncbi.nlm.nih.gov/pubmed/19940425
Omega-3 Polyunsaturated Fatty Acids in Prevention of Mood and Anxiety Disorders
Omega-3 Polyunsaturated Fatty Acids in Prevention of Mood and Anxiety Disorders
Summary
Nutrition is a modifiable environmental factor that might be important in prevention medicine. Omega-3 PUFAs are well tolerated and accepted, and have been applied for many years as the secondary prevention in various chronic medical diseases and mental disorders.
In this review, we found that the clinical evidence about omega-3 PUFAs’ preventive benefits on mood and anxiety disorders is supported by their regulatory effects on immunomodulation, anti-inflammation, signal transduction, neurotransmission and neuroprotection.
Our current review calls for more prospective clinical trials in identified high-risk populations to justify the preventive application of omega-3 PUFAs in daily practice.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540034/
Monday, April 24, 2017
Sunday, April 23, 2017
DeLonghi Electric Oven EO 3285 User Manual (Instructions for Use) 2014-12-10
DeLonghi Electric Oven EO 3285 User Manual (Instructions for Use) 2014-12-10. Posted here on 23 April 2017.
Only English sections and pictures are adapted here.
Page 1/37 to Page 4/37
Page 7/37 to Page 8/37
Page 25/37 to Page 37/37
Microwavable Lid: Instructions for microwavable lid large size.
Instructions for microwavable lid large size.
Thursday, April 20, 2017
What is Orthomolecular Medicine?
What is Orthomolecular Medicine?
Linus Pauling defined orthomolecular medicine as "the treatment of disease by the provision of the optimum molecular environment, especially the optimum concentrations of substances normally present in the human body."
Orthomolecular medicine uses safe, effective nutritional therapy to fight illness.
For more information: http://www.orthomolecular.org
Monday, April 17, 2017
Mixed pork-fish-vegetables-potato soup.
On 2017-04-17 at 6.30 pm, I cooked mixed pork-fish-vegetables-potato soup.
Total ingredient cost is between S$13.00 to S$15.00.
Ingredients:
1 litre plain water,
210g Ang-go-li fish (S$7.00+),
100g sliced pork (S$1.20)
100g minced pork (S$1.20),
1 Maggie ikan bilis stock cube (sodium 438 mg),
2 medium carrots,
3 big potatoes (S$2.00),
1 medium onion,
Some garlics,
4 pedals of vegetable Australian Wongbok.
Serves: 4 to 5.
Taste: Good.
No rice required.
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