My Weight 2018-11-28

My Weight
2018-11-28
1000 hr
61.5 kg
BMI 22.318

D-Mannose and UTI ( Urinary Tract infection)

https://m.scmp.com/lifestyle/health/article/1727680/cranberry-juice-little-use-curing-urinary-tract-infections?amp=1

Antibiotics can help clear UTIs, but what if you don't want to take them? Smith
says there is a "very effective" supplement called D-Mannose.

(Note: Sheena Smith, a naturopath and clinical nutritionist from the Integrated Medicine Institute.)

"This is the actual active, therapeutic ingredient taken from cranberries. The good news is that it is safe to consume, and can be used by children and pregnant women, and also on an ongoing basis for those suffering from chronic UTI," she says.

Maintaining the
healthy growth of good bacteria in your gut, and your bowel motions are also crucial, Smith says.

"Often, with the chronic use of antibiotics, stress and some vaginal washes and spermicides, the natural growth of good bacteria is compromised, allowing opportunistic bacteria to move into the urethra and cause issues," she says.

"There are specific probiotics available, like L. rhamnosus, L. reuteri, B. bifidus and B. lactis, for example, that are designed to survive the gastrointestinal tract and colonise the colon and vagina.

"They crowd out the other pathological organisms. If the E. coli form of bacterium is not present near the urethra, urinary tract infections are less likely.

"Supporting healthy gut flora might also help in aiding regular, well-formed bowel motions. Many infections are caused by stray bacteria - like E. coli - from the rectum moving to the urethra. This most commonly occurs when one is suffering from constipation or diarrhoea," Smith says.

Good daily habits are also necessary. For example, always wipe from front to back to minimise the transfer of bacteria from the rectum to the urethra.

To keep your immune system strong so that it can fight off the infection, it's important to eat well, exercise regularly and get enough sleep.

How to use D-mannose

https://www.healthline.com/health/d-mannose-for-uti#dosage

NEWSLETTER

Can D-Mannose Treat or Prevent UTIs?
Medically reviewed by Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT on April 19, 2018 — Written by Philip Gregory, PharmD
Research
Dosage
Side effects
Conclusion
What is D-mannose?
D-mannose is a type of sugar that’s related to the better-known glucose. These sugars are both simple sugars —that is, they consist of just one molecule of sugar. As well, both occur naturally in your body and are also found in some plants in the form of starch.

Several fruits and vegetables contain D-mannose, including:

cranberries (and cranberry juice)
apples
oranges
peaches
broccoli
green beans
This sugar is also found in certain nutritional supplements, available as capsules or powders. Some contain D-mannose by itself, while others include additional ingredients, such as:

cranberry
dandelion extract
hibiscus
rose hips
probiotics
Many people take D-mannose for treating and preventing urinary tract infections (UTIs). D-mannose is thought to block certain bacteria from growing in the urinary tract. But does it work?

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What the science says
E. coli bacteria cause 90 percent of UTIs. Once these bacteria enter the urinary tract, they latch on to cells, grow, and cause infection. Researchers think that D-mannose works for a UTI by preventing these bacteria from latching on.

After you consume foods or supplements containing D-mannose, your body eventually eliminates it through the kidneys and into the urinary tract. While in the urinary tract, it can attach to the E. coli bacteria that may be there. As a result, the bacteria can no longer attach to cells and cause infection.

There isn’t much research on the effects of D-mannose when taken by people who have UTIs, but a few early studies show that it might help.

A 2013 study evaluated D-mannose in 308 women who had frequent UTIs. D-mannose worked about as well as the antibiotic nitrofurantoin for preventing UTIs over a 6-month period.

In a 2014 study, D-mannose was compared to the antibiotic trimethoprim/sulfamethoxazole for treatment and prevention of frequent UTIs in 60 women. D-mannose reduced UTI symptoms in women with an active infection. It was also more effective than the antibiotic for preventing additional infections.

A 2016 study tested the effects of D-mannose in 43 women with an active UTI. At the end of the study, most women had improved symptoms.

How to use D-mannose

A lot of different D-mannose products are available. When deciding on which to use, you should consider three things:

whether you’re trying to prevent an infection or treat an active infection
the dose you’ll need to take
the type of product you want to take
D-mannose is typically used for preventing a UTI in people who have frequent UTIs or for treating an active UTI. It’s important to know which of these you are using it for because the dosage will differ.

The best dose to use isn’t entirely clear, however. For now, the doses that have been used in research are recommended:

For preventing frequent UTIs: 2 grams once daily, or 1 gram twice daily.

For treating an active UTI: 1.5 grams twice daily for 3 days, and then once daily for 10 days; or 1 gram three times daily for 14 days.
D-mannose comes in capsules and powders. The form you choose mainly depends on your preference. You might prefer a powder if you don’t like to take bulky capsules or want to avoid the fillers included in some manufacturers’ capsules.

Keep in mind that many products provide 500-milligram capsules. This means that you may need to take two to four capsules to get the desired dose.

To use D-mannose powder, dissolve it in a glass of water, and then drink the mixture. The powder dissolves easily, and the water will have a sweet taste.

D-mannose: a promising support for acute urinary tract infections in women. A pilot study.

D-mannose: a promising support for acute urinary tract infections in women. A pilot study.
.======
Domenici L, et al. Eur Rev Med Pharmacol Sci. 2016.
Show full citation
Abstract
OBJECTIVE: Urinary tract infections still represent a significant bother for women and result in high costs to the health system. D-mannose is a simple sugar; it seems able to hinder bacteria adhesion to the urothelium. The present study aimed to determine whether D-mannose alone is effective in treating acute urinary tract infections in women and its possible utility in the management of recurrences.

PATIENTS AND METHODS: This is a pilot study, performed between April 2014 and July 2015 at Department of Gynaecological Obstetrics and Urologic Sciences of "Sapienza" University of Rome. A D-mannose compound was administered twice daily for 3 days and then once a day for 10 days. Changes in patients' symptoms, the therapeutic effects and changes in quality of life (QoL) were evaluated clinically and using a specifically validated questionnaire (UTISA). After described treatment, patients were randomized in receiving or not prophylaxis in the next 6 months.

RESULTS: Mean UTISA scores recorded after completing the treatment, compared with baseline scores, showed a significant improvement of the majority of symptoms (p < 0.05). D-mannose seemed to have had a significant positive effect on UTIs' resolution and QoL improvement (p = 0.0001). As prophylactic agent administered for 6 months, it showed promising results (4.5% vs. 33.3% recurrences in treated and untreated patients respectively).

CONCLUSIONS: The results of this study suggest that D-mannose can be an effective aid in acute cystitis management and also a successful prophylactic agent in a selected population; however, more studies will certainly be needed to confirm the results of our pilot study.

PMID 27424995 [Indexed for MEDLINE]
Full text
Full text at journal site
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https://www.ncbi.nlm.nih.gov/m/pubmed/27424995/

Cystitis

Cystitis is an inflammation of the bladder. Inflammation is where part of your body becomes irritated, red, or swollen. In most cases, the cause of cystitis is a urinary tract infection (UTI). A UTI happens when bacteria enter the bladder or urethra and begin to multiply.

D-Mannose at doses of 8 to 20 grams per day has been shown to purge E. Coli bacteria from the urinary tract.

Invasion of the urinary tract (UT) by E. Coli bacteria causes most infections. 

D-Mannose at doses of 8 to 20 grams per day has been shown to purge E. Coli bacteria from the urinary tract. 

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