https://www.ncbi.nlm.nih.gov/pubmed/27199101
A multi-ingredient dietary supplement abolishes large-scale brain cell loss, improves sensory function, and prevents neuronal atrophy in aging mice.
Lemon JA1, Aksenov V2, Samigullina R2, Aksenov S3, Rodgers WH3, Rollo CD2, Boreham DR1,4.
Author information
Abstract
Transgenic growth hormone mice (TGM) are a recognized model of accelerated aging with characteristics including chronic oxidative stress, reduced longevity, mitochondrial dysfunction, insulin resistance, muscle wasting, and elevated inflammatory processes. Growth hormone/IGF-1 activate the Target of Rapamycin known to promote aging. TGM particularly express severe cognitive decline. We previously reported that a multi-ingredient dietary supplement (MDS) designed to offset five mechanisms associated with aging extended longevity, ameliorated cognitive deterioration and significantly reduced age-related physical deterioration in both normal mice and TGM. Here we report that TGM lose more than 50% of cells in midbrain regions, including the cerebellum and olfactory bulb. This is comparable to severe Alzheimer's disease and likely explains their striking age-related cognitive impairment. We also demonstrate that the MDS completely abrogates this severe brain cell loss, reverses cognitive decline and augments sensory and motor function in aged mice. Additionally, histological examination of retinal structure revealed markers consistent with higher numbers of photoreceptor cells in aging and supplemented mice. We know of no other treatment with such efficacy, highlighting the potential for prevention or amelioration of human neuropathologies that are similarly associated with oxidative stress, inflammation and cellular dysfunction. Environ. Mol. Mutagen. 57:382-404, 2016. © 2016 Wiley Periodicals, Inc.
© 2016 Wiley Periodicals, Inc.
KEYWORDS:
aging; multi-ingredient dietary supplement; neurodegeneration; neuroprotectant; oxidative stress
PMID: 27199101 DOI: 10.1002/em.22019
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https://www.reddit.com/r/Nootropics/comments/4mfsiz/2016_a_multiingredient_dietary_supplement/
Table 1 (from previous study detailing ingredients in mice dietary supplement). Formulation of a Dietary Supplement Designed to Reduce Oxidative Stress and Inflammation, Maintain Membrane and Mitochondrial Integrity, and Enhance Insulin Sensitivity.
Supplement / Dosage
Vitamin B1(b) 0.72 mg/day
Vitamin B3(b) 0.72 mg/day
Vitamin B6(b) 0.72 mg/day
Vitamin B12(b) 0.72 mcg/day
Vitamin C(b) 3.6 mg/day
Vitamin D(b) 2.5 IU/day
Vitamin E(b) 1.44 IU/day
Acetyl L-carnitine(c) 14.4 mg/day
Alpha-lipoic acid(e) 0.72 mg/day
ASA(d) 2.5 mg/day
Beta carotene(b) 50.0 IU/day
Bioflavinoids(h) 4.32 mg/day
Chromium picolinate(i) 1.44 mcg/day
Cod liver oil(b) 5.04 IU/day
CoEnzyme Q10(h) 0.44 mg/day
DHEA(g) 0.15 mg/day
Flax seed oil(h) 21.6 mg/day
Folic acid(b) 0.01 mg/day
Garlic(b) 21.6 mcg/day
Ginger(h) 7.2 mg/day
Gingko biloba(h) 1.44 mg/day
Ginseng (Canadian)(h) 8.64 mg/day
Green tea extracts(f) 7.2 mg/day
L-Glutathione(a) 0.36 mg/day
Magnesium(b) 0.72 mg/day
Melatonin(g) 0.01 mg/day
N-Acetyl cysteine(e) 7.2 mg/day
Potassium(b) 0.36 mg/day
Rutin(h) 0.72 mg/day
Selenium(h) 1.08 mcg/day
Zinc (chelated)(b) 0.14 mg/day
Notes: Vitamin brands are as follows: (a) = Cell Life; (b) = Jamieson vitamins; (c) = Jarrow Formulas; (d) = Lifebrand; (e) = Natural Factors; (f) = Naka; (g) = Promatrix; (h) = Swiss vitamins; (i) = Vitamin Power Inc.
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